Development of Innovative Foldamers for the Peptide Receptor Radionuclide Therapy of Tumours Overexpressing Cholecystokinin-2 Receptors

Grant number: 1158863 | Funding period: 2019 - 2022

Completed

Abstract

Peptide Receptor Radionuclide Therapy (PRRT) is a systematic treatment used to deliver high levels of radiation to cancer using radiopharmaceuticals known as theranostic agents (TAs). Until now TAs have been limited to only a few cancer types. This project aims to develop TAs to treat cancers which overexpress an important molecular target known as Cholecystokinin-2 (CCK-2) receptors. These TAs will be prepared in an innovative manner to display high affinity and stability for CCK-2 receptors.

Related publications (5)

Scholarly works icon

Correction: Evaluating the therapeutic efficacy of gastramide theranostics targeting cholecystokinin-2 receptors in a preclinical setting

MN Rahimi, JA Pinson, J Hilton-Proctor, J Van Zuylekom, B Blyth, PD Roselt, MB Haskali

2026-01-01

Correction for ‘Evaluating the therapeutic efficacy of gastramide theranostics targeting cholecystokinin-2 receptors in a preclini..

Scholarly works icon

Evaluating the therapeutic efficacy of gastramide theranostics targeting cholecystokinin-2 receptors in a preclinical setting

MN Rahimi, JA Pinson, J Hilton-Proctor, J Van Zuylekom, B Blyth, PD Roselt, MB Haskali

2026-01-01

Cholecystokinin-2 receptors (CCK<inf>2</inf>R) are overexpressed in neuroendocrine tumors, making them attractive targets for radi..

Scholarly works icon

Development of Highly Potent Clinical Candidates for Theranostic Applications against Cholecystokinin-2 Receptor Positive Cancers

A Corlett, JA Pinson, MN Rahimi, JV Zuylekom, C Cullinane, B Blyth, PE Thompson, CA Hutton, PD Roselt, MB Haskali

2023-08-10

Peptide receptor radionuclide therapy (PRRT) is a promising form of systemic radiation therapy designed to eradicate cancer. Chole..

Scholarly works icon

Investigation of Fluorine-18 Labelled Peptides for Binding to Cholecystokinin-2 Receptors with High Affinity

NUH Khan, A Corlett, CA Hutton, MB Haskali

2022-01-01

Many cancers of neuroendocrine origin overexpress cholecystokinin-2 receptors (CCK-2R) including medullary thyroid cancer, small c..

Scholarly works icon

A New Turn in Peptide-Based Imaging Agents: Foldamers Afford Improved Theranostics Targeting Cholecystokinin-2 Receptor-Positive Cancer

A Corlett, MA Sani, J Van Zuylekom, CS Ang, E Von Guggenberg, C Cullinane, B Blyth, RJ Hicks, PD Roselt, PE Thompson, CA Hutton, MB Haskali

2021-04-22

Proteins adopt unique folded secondary and tertiary structures that are responsible for their remarkable biological properties. Th..

University of Melbourne Researchers